ABSTRACT
Background: During the CoViD-19 pandemic in type 2 diabetic patients (T2DM pts) present in our Medicine wards we administered a big amount of s.c. insulin through the basal bolus regimen in order to obtain a good metabolic control;often difficult to reach both for the septic state and steroid therapy. Since we administered almost 60 to 80 units/insulin per day (TDD), not always obtaining a good metabolic control, we thought to switch some of our in-patients treated with basal bolus insulin regimen to a bolus plus a fixed ratio combination of GLP1-RA/basal insulin trying to take advantage of both the antiinflammatory and slimming effect of GLP1-RA. Results: Between October and December 2020 we evaluated 54 T2DM in-patients with CoViD-19 pneumonia.They were 41 males and 13 females aged 70±5 yrs, BMI 31±3kg/sm with an average HbA1c 8.3±1.2 and an insulin TDD of 70±11 s.c. compared to 40 matched (for sex, age, BMI and insulin TDD) control pts treated with basal bolus regimen. Conclusions:We detected in the fixed ratio combination of GLP1- RA/basal insulin a faster and stable good metabolic control vs the basal bolus treated pts. We reduced the average amount of insulin TDD of 34% with great satisfaction of pts and nurses.